甲基2-甲氧基-1-吡咯烷羧酸酯合成路线 （共 27 条）
反应条件
1: in dichloromethane T=-78°C; 1 h; Inert atmosphere; 2: With boron trifluoride diethyl etherate in dichloromethane T=-78°C; Inert atmosphere;
参考文献
Kirira, Peter G.; Kuriyama, Masami; Onomura, Osamu
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 3970 - 3982
反应条件
1: 92 percent / TiCl4 / CH2Cl2 / 1 h / 0 °C 2: 57 percent / LDA / tetrahydrofuran / 1 h / -78 °C 3: 74 percent / tetraethylammonium p-toluenesulfonate / acetonitrile / carbon rod anode; zinc cathode; 4.5 F/mol View Scheme
参考文献
Shono, Tatsuya; Terauchi, Jun; Kitayama, Kenji; Takeshima, Yo-Ichiro; Masumura, Yoshihiro
Tetrahedron, 1992 , vol. 48, # 38 p. 8253 - 8262
参考文献
Shono, Tatsuya; Terauchi, Jun; Kitayama, Kenji; Takeshima, Yo-Ichiro; Masumura, Yoshihiro
Tetrahedron, 1992 , vol. 48, # 38 p. 8253 - 8262
反应条件
1: (2S)-pyrrolidine-1,2-dicarboxylic acid 1-methyl ester With [bis(acetoxy)iodo]benzene; iodine in dichloromethane
T=20°C; oxidative decarboxylation; 3 h;
2: methanol T=20°C; Methylation; 0.75 h; Further stages.;
参考文献
Boto, Alicia; Hernandez, Rosendo; Suarez, Ernesto
Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 4930 - 4937
反应条件
[bis(acetoxy)iodo]benzene; iodine in dichloromethane
T=20°C; Decarboxylation; 3 h;
参考文献
Boto, Alicia; Hernandez, Rosendo; Suarez, Ernesto
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5945 - 5948
反应条件
tetraethylammonium tetrafluoroborate in acetonitrile
T=0°C; Electrochemical reaction;
参考文献
Kirira, Peter G.; Kuriyama, Masami; Onomura, Osamu
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 3970 - 3982
反应条件
tetraethylammonium tetrafluoroborate in acetonitrile
T=-10°C; Electrochemical reaction;
参考文献
Kirira, Peter G.; Kuriyama, Masami; Onomura, Osamu
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 3970 - 3982
反应条件
1: 1-(mesyloxy)-3-methoxypiperidin-2-one in dichloromethane
T=-78°C; 1.5 h; UV-irradiationInert atmosphere;
2: methanol With triethylamine in dichloromethane
16 h; Inert atmosphere;
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: 1-chloro-3-methoxypiperidin-2-one in dichloromethane
T=-78°C; 4.5 h; UV-irradiationInert atmosphere;
2: methanol With potassium carbonate
T=20°C; 16 h; Inert atmosphere;
参考文献
Winter, Dana K.; Drouin, Alexandre; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2610 - 2618
反应条件
1: 1-(methoxycarbonyl)-DL-proline With [bis(acetoxy)iodo]benzene; iodine in dichloromethane
2 h; Reflux;
2: methanol in dichloromethane
T=25°C; 0.5 h;
参考文献
Boto, Alicia; Hernandez, Dacil; Hernandez, Rosendo
European Journal of Organic Chemistry, 2010 , # 34 p. 6633 - 6642
