4-羟基-2-(2-吡啶)-5-嘧啶羧酸合成路线 （共 2 条）
反应条件
1: With sodium methylate in methanol Reflux; 2: With water; potassium hydroxide in methanol 2 h; Reflux; 3: With hydrogenchloride in methanol; water T=20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere 1.2: 4 h / 20 °C 2.1: sodium methylate / methanol / Reflux 2.2: 2 h / Reflux 2.3: 2 h / 20 °C View Scheme
参考文献
WO2011/130908 A1, ;
WO 2011/130908 A1
WO2011/133444 A1, ;
WO 2011/133444 A1
