1,4-双(溴甲基)-2,5-二碘苯合成路线 （共 8 条）
反应条件
bromine in ethylene dibromide
T=135°C; Inert atmosphere;
参考文献
Lin, Yi-Chun; Lin, Chih-Hsiu; Chen, Chan-Yu; Sun, Shih-Sheng; Pal, Bikash
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 12 p. 4507 - 4517
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran
T=20°C; Appel reaction;
参考文献
Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd
Synthesis, 2006 , # 17 p. 2971 - 2973
反应条件
N-bromosuccinmide; dibenzoyl peroxide in chloroform
UV-irradiation; Title compound not separated from byproducts.;
参考文献
Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd
Synthesis, 2006 , # 17 p. 2971 - 2973
反应条件
1: sulfuric acid; iodine; acetic acid; potassium iodide / water / 6 h / Inert atmosphere; Reflux
2: bromine / ethylene dibromide / 135 °C / Inert atmosphere
View Scheme
参考文献
Lin, Yi-Chun; Lin, Chih-Hsiu; Chen, Chan-Yu; Sun, Shih-Sheng; Pal, Bikash
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 12 p. 4507 - 4517
反应条件
1: 89 percent / aq. NaOH / methanol / Heating
2: 81 percent / CBr4; PPh3 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd
Synthesis, 2006 , # 17 p. 2971 - 2973
反应条件
1: 92 percent / pyridine / tetrahydrofuran / 20 °C
2: 23 percent / HIO3; I2; H2SO4 / acetic acid; CCl4 / 15 h / Heating
3: 89 percent / aq. NaOH / methanol / Heating
4: 81 percent / CBr4; PPh3 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd
Synthesis, 2006 , # 17 p. 2971 - 2973
反应条件
1: 23 percent / HIO3; I2; H2SO4 / acetic acid; CCl4 / 15 h / Heating
2: 89 percent / aq. NaOH / methanol / Heating
3: 81 percent / CBr4; PPh3 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd
Synthesis, 2006 , # 17 p. 2971 - 2973
反应条件
1: NaH / tetrahydrofuran
View Scheme
参考文献
Zucchero, Anthony J.; Wilson, James N.; Bunz, Uwe H. F.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11872 - 11881
