5-氟吲哚-2-酮合成路线

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Natco Pharma Limited
Patent: US2011/92717 A1, 2011 ;
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参考文献

SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD.; HENSCHKE, Julian, P.; CHEN, Yung-Fa
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56341-41-45-氟吲哚-2-酮+

356068-86-5N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺

341031-54-7苹果酸舒尼替尼

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

56341-41-45-氟吲哚-2-酮

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
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123-75-1四氢吡咯+

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸+

56341-41-45-氟吲哚-2-酮

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

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Tang, Peng Cho; Miller, Todd A.; Li, Xiaoyuan; Sun, Li; Wei, Chung Chen; Shirazian, Shahrzad; Liang, Congxin; Vojkovsky, Tomas; Nematalla, Asaad S.; Hawley, Michael
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110-89-4哌啶+

253870-02-92,4-二甲基-5-醛基-1H-吡咯-3-羧酸

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

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SUGEN, INC.
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56341-41-45-氟吲哚-2-酮

356068-93-45-((Z)-(5-氟-2-氧代吲哚烷-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-羧酸

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;

342642-56-2+

56341-41-45-氟吲哚-2-酮

356068-94-5托西尼布

参考文献

PHARMACIA and UPJOHN COMPANY
Patent: WO2004/76410 A2, 2004 ;
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WO 2004/076410 A2

56341-41-45-氟吲哚-2-酮+

356068-86-5N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺

557795-19-4舒尼替尼

参考文献

SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
Location in patent: Paragraph 0062; 0063; 0064; 0065; 0071; 0085 ;

56341-41-45-氟吲哚-2-酮+

3724-43-4(氯亚甲基)二甲基氯化铵+

590424-05-8N-(2-(二乙基氨基)乙基)-2,4-二甲基-1H-吡咯-3-甲酰胺

557795-19-4舒尼替尼

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Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
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