2,3-二氯四氢-2H-吡喃合成路线 （共 44 条）
反应条件
1: 101 g / diethyl ether; tetrahydrofuran / 4 h / -5 °C
2: Na / diethyl ether / 1.5 h / Heating
3: pyridinium chlorochromate / CH2Cl2 / 1.25 h / Heating
4: 3-(2-ethoxyethyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / triethylamine; dioxane / 15 h / 87 °C
5: 1.) NaOH, 2.) NaBH4 / 1.) EtOH-H2O, reflux, 0.5 h, 2.) 2 h
View Scheme
参考文献
Voaden, Denys J.
Synthetic Communications, 1984 , vol. 14, # 1 p. 53 - 64
反应条件
1: diethyl ether
2: potassium hydroxide; ethylene glycol
View Scheme
参考文献
Riobe
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 628
反应条件
magnesium
ether; Yield given. Multistep reaction;
参考文献
Crombie, Leslie; Wyvill, Robert D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1971 - 1982
反应条件
1: 101 g / diethyl ether; tetrahydrofuran / 4 h / -5 °C
2: Na / diethyl ether / 1.5 h / Heating
3: pyridinium chlorochromate / CH2Cl2 / 1.25 h / Heating
View Scheme
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
