4-(3-羟基苯氧基)苯甲酸合成路线 （共 5 条）
反应条件
hydrogen bromide; acetic acid 12 h; Reflux;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank, I.; THOMAS, James, B.; NAVARRO, Hernan, A.; MASCARELLA, S., Wayne; RUNYON, Scott, P.; JIN, Chunyang; KORMOS, Chad, M.
Patent: WO2013/86496 A2, 2013 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 36 percent / copper bronze, potassium carbonate / pyridine / 144 h / Heating 2: KOH / ethanol; H2O / 18 h / Heating 3: 1.) pyridine hydrochloride, 2.) water / 1.) 180-185 deg C, 3 h, 2.) RT, 18 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1726 - 1734
反应条件
1: KOH / ethanol; H2O / 18 h / Heating 2: 1.) pyridine hydrochloride, 2.) water / 1.) 180-185 deg C, 3 h, 2.) RT, 18 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1726 - 1734
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 175 °C / |Sealed tube 2: Jone's reagent / acetone 3: hydrogen bromide; acetic acid / 12 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4551 - 4567
反应条件
1: KMnO4 2: HI; acetic acid; acetic acid anhydride View Scheme
参考文献
Journal of Organic Chemistry, , vol. 16, p. 1311,1313
