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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
56164-42-2
合成路线
（共 10 条）
1121-76-2
4-氯吡啶 N-氧化物
→
反应条件
56164-42-2
反应条件
CuSO4‵5H2O in water T=20°C; 18 h; UV-irradiation;
参考文献
Clark, Benjamin R.; Murphy, Cormac D.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 1 p. 111 - 116
68-12-2
N,N-二甲基甲酰胺
+
153633-34-2
→
反应条件
56164-42-2
反应条件
1: 3-chloro-1-(p-toluenesulfonyl)pyrrole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 1.25 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; Formylation; detosylation; 1 h;
参考文献
Robertson, Jeremy; Kuhnert, Nikolai; Zhao, Yuekun
Heterocycles, 2000 , vol. 53, # 11 p. 2415 - 2420
68-12-2
N,N-二甲基甲酰胺
+
153633-34-2
→
反应条件
56164-42-2
+
171626-90-7
反应条件
1: 3-chloro-1-(p-toluenesulfonyl)pyrrole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; Formylation; 1 h;
参考文献
Robertson, Jeremy; Kuhnert, Nikolai; Zhao, Yuekun
Heterocycles, 2000 , vol. 53, # 11 p. 2415 - 2420
1314983-39-5
→
反应条件
56164-42-2
反应条件
“IBX”; sodium hydrogencarbonate in dimethyl sulfoxide T=20°C; 16 h;
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
872-32-2
2-甲基-吡咯啉
→
反应条件
56164-42-2
反应条件
1: N-chloro-succinimide / tetrahydrofuran / 0.33 h / 55 °C 2: methanol / 0 - 20 °C 3: hydrogenchloride / methanol; water / 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C 5: “IBX”; sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
89581-82-8
2-乙酰基-3-氯噻吩
→
反应条件
56164-42-2
反应条件
1.1: pyridine; iodine; copper(II) oxide / ethanol / 16 h / Reflux 1.2: 2 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
153562-66-4
3-氯噻吩-2-羧酸乙酯
→
反应条件
56164-42-2
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 2: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
226410-00-0
3-氯-1H-吡咯-2-羧酸甲酯
→
反应条件
56164-42-2
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C 2: “IBX”; sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
226409-98-9
→
反应条件
56164-42-2
反应条件
1: hydrogenchloride / methanol; water / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C 3: “IBX”; sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
226409-94-5
→
反应条件
56164-42-2
反应条件
1: methanol / 0 - 20 °C 2: hydrogenchloride / methanol; water / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C 4: “IBX”; sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 20 °C View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
