2-(1H-吡咯[2,3-B]并吡啶)-3-乙酸合成路线 （共 14 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing
Patent: WO2011/31554 A2, 2011 ;
Location in patent: Page/Page column 170 ;
WO 2011/031554 A1
反应条件
1: methyl 3-cyclopropyl-2,3-epoxypropionate With sodium hydroxide in water T=25°C; 3 h; 2: hydrogenchloride in water T=25°C; 1.5 h;
参考文献
Kuraray Co., Ltd.
Patent: EP1445248 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
in hydrogenchloride; ethyl acetate; Petroleum ether
参考文献
Pharmacia Italis S.p.A.
Patent: US2005/4120 A1, 2005 ;
US 20050004120 A1
反应条件
1: With diisobutylaluminium hydride in dichloromethane T=0°C; 3 h; 2: With methanol; sodium hydrogen sulphate; water in dichloromethane T=20°C; 4 h;
参考文献
WO2009/58919 A1, ;
Page/Page column 42-43 ;
WO 2009/058919 A1
反应条件
triethylamine in dichloromethane; water
参考文献
Pevarello, Paolo; Amici, Raffaella; Traquandi, Gabriella; Villa, Manuela; Vulpetti, Anna; Isacchi, Antonella
Patent: US2003/187040 A1, 2003 ;
反应条件
1: LiAlH4 / diethyl ether 2: aq. HCl, NaNO2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 40, p. 961 - 963
反应条件
1: LiAlH4 / diethyl ether 2: CrO3, Py View Scheme
参考文献
Journal of Organic Chemistry, , vol. 29, # 7 p. 1663 - 1669
反应条件
hydrogenchloride; sodium nitrite
参考文献
Journal of Organic Chemistry, , vol. 40, p. 961 - 963
参考文献
Tetrahedron, , vol. 33, p. 77 - 84
