缩胆囊素片段 (30-33) 酰胺盐酸盐合成路线 （共 10 条）
反应条件
4-methyl-morpholine 48 h;
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
hydrogenchloride in acetic acid
T=20°C; 1 h;
参考文献
Sadovnikova, N. V.; Fedotov, V. P.; Shvachkin, Yu. P.; Shishkina, A. A.; Kolomeitseva, L. A.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 838 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1424 - 1427
反应条件
hydrogenchloride; acetic acid; ethanethiol
0.75 h; Ambient temperature;
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DMF, 15 min, -18 deg C; 2.) 2 h, -10 - -20 deg C; 4 h, room temperature
2: 84 percent / H2 / Pd black / methanol / 12 h
3: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
4: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 84 percent / H2 / Pd black / methanol / 12 h
2: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
3: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 1.) Et3N / 1.) DMF, -10 deg C, 2.) 20 deg C, 1 h
2: 92 percent / HCl / acetic acid / 1 h / 20 °C
View Scheme
参考文献
Sadovnikova, N. V.; Fedotov, V. P.; Shvachkin, Yu. P.; Shishkina, A. A.; Kolomeitseva, L. A.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 838 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1424 - 1427
反应条件
1: 1.) tritone B / 1.) DMF; 2.) DMF, 5 h
2: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
3: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
2: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
2: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
反应条件
1: 1.) tritone B / 1.) DMF; 2.) DMF, 5 h
2: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
3: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
