beta-环香叶基三苯基鏻溴化物合成路线 （共 7 条）
反应条件
in methanol
T=20°C; 18 h;
参考文献
ACUCELA INC.
Patent: WO2008/131368 A2, 2008 ;
Location in patent: Page/Page column 134; 136 ;
反应条件
1: LiAlH4 / diethyl ether / 0 °C
2: PBr3 / diethyl ether; pentane / 1.) -30 deg C, 2 h, 2.) room temperature, overnight
3: 22 percent / ethyl acetate / 1 h / Heating
View Scheme
参考文献
Andrewes, Arthur G.; Borch, Gunner; Liaaen-Jensen, Synnoeve
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 10 p. 871 - 876
反应条件
1: PBr3 / diethyl ether; pentane / 1.) -30 deg C, 2 h, 2.) room temperature, overnight
2: 22 percent / ethyl acetate / 1 h / Heating
View Scheme
参考文献
Andrewes, Arthur G.; Borch, Gunner; Liaaen-Jensen, Synnoeve
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 10 p. 871 - 876
反应条件
in ethyl acetate
1 h; Heating;
参考文献
Andrewes, Arthur G.; Borch, Gunner; Liaaen-Jensen, Synnoeve
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 10 p. 871 - 876
反应条件
potassium tert-butylate
1.) t-BuOH, THF, 0 deg C, 15 min, 2.) t-BuOH, THF, a) 0 deg C, 2 h, b) RT, 18 h; Yield given. Multistep reaction;
参考文献
Dawson; Hobbs; Chan; Chao; Fung
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 583 - 592
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF, RT, 24 h
2: 75 percent / KOH / methanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca L.-S.; Derdzinski, Krzysztof; Hobbs, Peter D.; Chao, Wan-Ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1653 - 1656
反应条件
sodium hexamethyldisilazane
1.) benzene, 1 h, reflux; 2.) 12 h, room temperature; Yield given. Multistep reaction;
参考文献
Bestmann; Ermann
1984 , vol. 1984, # 10 p. 1740 - 1745
