反应条件
1: para-methylacetophenone With sodium t-butanolate in tetrahydrofuran
T=20°C; 0.333333 h;
2: With 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran
0.166667 h;
3: 3-chloro-6-methoxy-pyridazine in tetrahydrofuran
T=75°C; 1 h;
参考文献
ASTELLAS PHARMA INC.; WAKUNAGA PHARMACEUTICAL CO., LTD.
Patent: WO2006/38734 A1, 2006 ;
Location in patent: Page/Page column 54 ;