3,4-二氯吡啶合成路线

Schroeder, Gretchen M.; An, Yongmi; Cai, Zhen-Wei; Chen, Xiao-Tao; Clark, Cheryl; Cornelius, Lyndon A. M.; Dai, Jun; Gullo-Brown, Johnni; Gupta, Ashok; Henley, Benjamin; Hunt, John T.; Jeyaseelan, Robert; Kamath, Amrita; Kim, Kyoung; Lippy, Jonathan; Lombardo, Louis J.; Manne, Veeraswamy; Oppenheimer, Simone; Sack, John S.; Schmidt, Robert J.; Shen, Guoxiang; Stefanski, Kevin; Tokarski, John S.; Trainor, George L.; Wautlet, Barri S.; Wei, Donna; Williams, David K.; Zhang, Yingru; Zhang, Yueping; Fargnoli, Joseph; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1251 - 1254

55934-00-43,4-二氯吡啶+

124-38-9二氧化碳

959578-03-13,4-二氯吡啶-2-甲酸+

473837-10-43,4-二氯-5-吡啶羧酸

参考文献

Marzi, Elena; Bigi, Anna; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376

55934-00-43,4-二氯吡啶+

68-12-2N,N-二甲基甲酰胺

1009334-04-64,5-二氯-3-吡啶羧醛

参考文献

F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/66061 A1, 2012 ;
Location in patent: Page/Page column 122 ;
WO 2012/066061 A1

55934-00-43,4-二氯吡啶+

201230-82-2+

98-80-6苯硼酸

参考文献

Maerten, Eddy; Sauthier, Mathieu; Mortreux, Andre; Castanet, Yves
Tetrahedron, 2007 , vol. 63, # 3 p. 682 - 689