8-甲氧基-2,6-二甲基辛-2-烯合成路线 （共 6 条）
反应条件
sodium hydride
1.) DMSO, 1h 2.) 15h; Yield given. Multistep reaction;
参考文献
Phadnis, A. P.; Nanda, B.; Patwardhan, Sarita A.; Powar, P.; Sharma, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 9 p. 867 - 870
反应条件
1: 52 percent / LDA / tetrahydrofuran; hexane / 1) -75 deg C, 1 h, 2) 20 deg C, 1 h
2: 67 percent / NH3, Li / diethyl ether / 1.5 h / -40 °C
3: 83 percent / NaH / dimethylsulfoxide / 17 h / 20 °C
4: aq. pyridinium tosylate / acetone / 2 h / Heating
5: 1.) BuLi / 1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Zainullin, R. A.; Kasradze, V. G.; Lolidze, A. V.; Tolstikov, G. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.1 p. 919 - 922
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 6 p. 1178 - 1182
反应条件
1: 67 percent / NH3, Li / diethyl ether / 1.5 h / -40 °C
2: 83 percent / NaH / dimethylsulfoxide / 17 h / 20 °C
3: aq. pyridinium tosylate / acetone / 2 h / Heating
4: 1.) BuLi / 1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Zainullin, R. A.; Kasradze, V. G.; Lolidze, A. V.; Tolstikov, G. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.1 p. 919 - 922
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 6 p. 1178 - 1182
反应条件
1: 83 percent / NaH / dimethylsulfoxide / 17 h / 20 °C
2: aq. pyridinium tosylate / acetone / 2 h / Heating
3: 1.) BuLi / 1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Zainullin, R. A.; Kasradze, V. G.; Lolidze, A. V.; Tolstikov, G. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.1 p. 919 - 922
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 6 p. 1178 - 1182
反应条件
1: aq. pyridinium tosylate / acetone / 2 h / Heating
2: 1.) BuLi / 1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Zainullin, R. A.; Kasradze, V. G.; Lolidze, A. V.; Tolstikov, G. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.1 p. 919 - 922
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 6 p. 1178 - 1182
反应条件
n-butyllithium
1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h; Yield given. Multistep reaction;
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Zainullin, R. A.; Kasradze, V. G.; Lolidze, A. V.; Tolstikov, G. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.1 p. 919 - 922
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 6 p. 1178 - 1182
