2,6-二甲氧基嘧啶-4-羧酸甲酯合成路线 （共 4 条）
反应条件
potassium carbonate in acetonitrile
T=20 - 85°C; 18.5 h;
参考文献
Jasco Pharmaceuticals, LLC
Patent: US2011/152235 A1, 2011 ;
Location in patent: Page/Page column 80 ;
反应条件
1.1: POCl3 / 120 °C
1.2: PCl5 / Heating
2.1: 6.48 g / H2O / 10 h / 20 °C
View Scheme
参考文献
Xie, Chaoyu; Runnegar, Maria T. C.; Snider, Barry B.
Journal of the American Chemical Society, 2000 , vol. 122, # 21 p. 5017 - 5024
反应条件
in water
T=20°C; Gershon's procedure; 10 h;
参考文献
Xie, Chaoyu; Runnegar, Maria T. C.; Snider, Barry B.
Journal of the American Chemical Society, 2000 , vol. 122, # 21 p. 5017 - 5024
反应条件
1: 97 percent / trifluoroacetic anhydride, N-iodosuccinimide / trifluoroacetic acid / 8 h / Heating
2: 85 percent / pyridine / 2 h / Heating
View Scheme
参考文献
Bhatt; Kundu; Chwang; Heidelberger
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 771 - 774
