1，2-二(溴甲基)-4-氟苯合成路线 （共 7 条）
参考文献
Aitken, R. Alan; Hodgson, Philip K.G.; Morrison, John J.; Oyewale, Adebayo O.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 402 - 415
反应条件
1: potassium carbonate / butanone / 16 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / water; tetrahydrofuran / 7 h / 40 °C / 760.05 Torr View Scheme
参考文献
DSM PHARMA CHEMICALS REGENSBURG GMBH; ERMANN, Peter Hans
Patent: WO2011/9928 A1, 2011 ;
反应条件
1: 81 percent / dimethylformamide / 9 h / Heating 2: 2 percent / 5N aq. lithium hydroxide / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Rice, Joseph E.; Czech, Anna; Hussain, Nalband; LaVoie, Edmond J.
Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1775 - 1779
反应条件
phosphorus tribromide in dichloromethane
T=0°C; 0.75 h;
参考文献
SANOFI-AVENTIS
Patent: WO2008/151211 A1, 2008 ;
Location in patent: Page/Page column 54-55 ;
WO 2008/151211 A1
反应条件
bromine in tetrachloromethane
参考文献
Aitken, R. Alan; Hodgson, Philip K.G.; Morrison, John J.; Oyewale, Adebayo O.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 402 - 415
反应条件
1: 1.) NaNO2, 60percent HBF4 / 1.) H2O, 0 deg C, 20 min, 2.) 80 deg C, 45 min
2: 37 percent / NBS, benzoyl peroxide / CCl4 / 0.75 h / Heating
View Scheme
参考文献
Rice, Joseph E.; Czech, Anna; Hussain, Nalband; LaVoie, Edmond J.
Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1775 - 1779
反应条件
1: LiAlH4 / tetrahydrofuran
2: 48percent HBr / Heating
View Scheme
参考文献
King, Geoff; Higgins, Simon J.
Journal of the Chemical Society, Chemical Communications, 1994 , # 7 p. 825 - 826
