2-哌嗪-1-基-1,3-苯并噻唑合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in methanol; water 12 h; Heating / reflux;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.
Patent: WO2008/153325 A1, 2008 ;
Location in patent: Page/Page column 25-26 ;
反应条件
hydrogen bromide in water T=70°C; 24 h;
参考文献
Hofer, Sandra; Kratschmar, Denise V.; Schernthanner, Brigitte; Vuorinen, Anna; Schuster, Daniela; Odermatt, Alex; Easmon, Johnny
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5397 - 5400
反应条件
1: piperazine With copper(l) iodide 0.5 h; 2: With potassium hydroxide in water 1 h; 3: 2-chloro-1,3-benzothiazole With benzyl-tri-(n-butyl)-ammonium bromide in chloroform; water T=20°C; 6 h; chemoselective reaction;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 5 p. 1324 - 1327
反应条件
sodium hydrogencarbonate in ethanol Heating;
参考文献
Journal of medicinal chemistry, , vol. 15, # 6 p. 693 - 694
反应条件
1.1: macroporous polymer-supported carbonate / dimethylsulfoxide / 100 °C 1.2: macroporous polymer-supported isocyanate / CH2Cl2 / 60 °C 2.1: macroporous polymer-supported-SO3H / CH2Cl2 / 20 °C 2.2: aq. NH3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 15 p. 2549 - 2552
反应条件
in methanol; water UV-irradiation;
参考文献
Tetrahedron Letters, , vol. 44, # 8 p. 1559 - 1561
反应条件
1: aq. KMnO4, AcOH / 2 h / 25 °C 2: 9.30 g / 4 h / 130 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 707 - 718
反应条件
1: 1.) NaH / 1.) DMF, a) 0 deg C, 20 min, b) RT, 30 min, 2.) DMF, RT, 1 h 2: aq. KMnO4, AcOH / 2 h / 25 °C 3: 9.30 g / 4 h / 130 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 707 - 718
参考文献
Orjales; Bordell; Rubio
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 707 - 718
参考文献
US6660751 B1, ;
Page column 8 ;
