1-(2-氯-6-羟基苯基)乙酮合成路线 （共 7 条）
反应条件
hydrogenchloride in tetrahydrofuran; water T=65°C; 3 h;
参考文献
WO2010/94120 A1, ;
Page/Page column 58-59 ;
WO 2010/094120 A1
反应条件
1: in tetrahydrofuran; toluene T=20 - 65°C; Inert atmosphereSealed tube; 2: With hydrogenchloride in tetrahydrofuran; water; toluene
参考文献
SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann
Patent: WO2010/56631 A1, 2010 ;
Location in patent: Page/Page column 132-134 ;
WO 2010/056631 A1
反应条件
titanium tetrachloride in dichloromethane
参考文献
Uto, Yoshikazu; Ueno, Yuko; Kiyotsuka, Yohei; Miyazawa, Yuriko; Kurata, Hitoshi; Ogata, Tsuneaki; Yamada, Makiko; Deguchi, Tsuneo; Konishi, Masahiro; Takagi, Toshiyuki; Wakimoto, Satoko; Ohsumi, Jun
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 4788 - 4796
反应条件
boron tribromide in dichloromethane T=-78 - 23°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 619 - 622
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C 2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -75 °C 2.2: -75 - 20 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 3 h / 65 °C View Scheme
参考文献
WO2011/11872 A1, ;
WO 2011/011872 A1
反应条件
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -75 °C 1.2: -75 - 20 °C 2.1: hydrogenchloride / water; tetrahydrofuran / 3 h / 65 °C View Scheme
参考文献
WO2011/11872 A1, ;
WO 2011/011872 A1
反应条件
1.1: tetrahydrofuran / 6 h / Reflux 1.2: 20 h / 75 °C 2.1: boron tribromide / dichloromethane / 1 h / -78 - 23 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 619 - 622
