<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=40&deg;C;&nbsp;8&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: NEt₃ / CCl₄ / 2 h<br />2: NaOH / H₂O / 1.) -7 deg C, 24 h; 2.) 100 deg C, 8 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: NaOH / ethanol; H₂O / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 20 percent / Cu₂O, CuCl, dibutylamine / 1 h / 100 - 110 &deg;C<br />2: 87 percent / Zn/Cu / methanol<br />3: 80 percent / HCl / 4 h / Ambient temperature<br />4: NaOMe / methanol / 2 h / 50 &deg;C<br />5: 95 percent / NaOH / methanol / 8 h / 40 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '13134392', constants.ctx, '0')">phosphate buffer</a> <br />T=25&deg;C;&nbsp;&nbsp;pig's liver esterase;&nbsp;&nbsp;Title compound not separated from byproducts;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 80 percent / HCl / 4 h / Ambient temperature<br />2: NaOMe / methanol / 2 h / 50 &deg;C<br />3: 95 percent / NaOH / methanol / 8 h / 40 &deg;C<br /> <br /> &nbsp;