6-氟喹喔啉-2-(1H)-酮合成路线 （共 12 条）
反应条件
in ethanol; toluene T=20°C; 2 h;
参考文献
WO2006/134378 A1, ;
Page/Page column 131 ;
WO 2006/134378 A1
反应条件
1: 44 percent / K2CO3 / dimethylformamide; H2O / 1 h / 80 °C 2: H2 / Pd/C / ethanol / 20 °C 3: aq. H2O2; NaOH / methanol / 1.5 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 2 p. 255 - 267
反应条件
1: H2 / Pd/C / ethanol / 20 °C 2: aq. H2O2; NaOH / methanol / 1.5 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 2 p. 255 - 267
反应条件
sodium tetrahydroborate in water T=25 - 30°C; 1.5 h; Yield given;
参考文献
Heterocycles, , vol. 23, # 1 p. 143 - 151
反应条件
1: 16percent NaOH / 1.5 h / 60 - 65 °C 2: NaBH4 / H2O / 1.5 h / 25 - 30 °C View Scheme
参考文献
Heterocycles, , vol. 23, # 1 p. 143 - 151
反应条件
potassium carbonate in ethanol 4.5 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 48, # 37 p. 7887 - 7898
反应条件
sodium hydroxide; dihydrogen peroxide 0.25 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 1 p. 93 - 101
反应条件
in ethyl acetate; trichlorophosphate
参考文献
Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael
Patent: US2013/115190 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
trichlorophosphate in N,N-dimethyl-formamide 1.5 h; Heating;
参考文献
Makino, Kenzi; Sakata, Gozyo; Morimoto, Katsushi
Heterocycles, 1985 , vol. 23, # 8 p. 2025 - 2034
反应条件
in ethyl acetate; trichlorophosphate
参考文献
Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael
Patent: US2013/115190 A1, 2013 ;
Location in patent: Page/Page column ;
