2-苄氧基-4-溴甲基-1-甲氧基苯合成路线 （共 8 条）
反应条件
1: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 2: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 3: K2CO3 / acetone / 14 h / Heating 4: lithium aluminum hydride / tetrahydrofuran / Heating 5: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme
参考文献
Meyers, A. I.; Guiles, Joseph
Heterocycles, 1989 , vol. 28, # 1 p. 295 - 301
反应条件
phosphorus tribromide in tetrahydrofuran
T=0°C; 1.5 h;
参考文献
Potter, Barry Victor Lloyd; Woo, Lok Wai Lawrence; Purohit, Atul; Reed, Michael John; Sutcliffe, Oliver Brook; Bubert, Christian
Patent: US2004/19016 A1, 2004 ;
Location in patent: Page/Page column 47 ;
反应条件
1: NaBH4 / tetrahydrofuran; ethanol / 0 - 20 °C
2: PBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 89 percent / NaHCO3; KI / acetonitrile / 10 h / Heating
2: 96 percent / NaBH4 / methanol / 2 h / 20 °C
3: 85 percent / PBr3; pyridine / diethyl ether / 2 h / Heating
View Scheme
参考文献
Yang, Peng-Yu; Zhou, Yong-Gui
Tetrahedron Asymmetry, 2004 , vol. 15, # 7 p. 1145 - 1149
反应条件
1: potassium carbonate / acetone / 4 h / Reflux; Inert atmosphere
2: phosphorus tribromide / dichloromethane / 1.33 h / -5 - 20 °C
View Scheme
参考文献
Taylor, Laura L.; Goldberg, Frederick W.; Hii, King Kuok Mimi
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 22 p. 4424 - 4432
反应条件
1: potassium carbonate / acetone / 4 h / Reflux; Inert atmosphere
2: phosphorus tribromide / dichloromethane / 1.33 h / -5 - 20 °C
View Scheme
参考文献
Taylor, Laura L.; Goldberg, Frederick W.; Hii, King Kuok Mimi
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 22 p. 4424 - 4432
反应条件
1: 89 percent / NaHCO3; KI / acetonitrile / 10 h / Heating
2: 96 percent / NaBH4 / methanol / 2 h / 20 °C
3: 85 percent / PBr3; pyridine / diethyl ether / 2 h / Heating
View Scheme
参考文献
Yang, Peng-Yu; Zhou, Yong-Gui
Tetrahedron Asymmetry, 2004 , vol. 15, # 7 p. 1145 - 1149
反应条件
1: 50 percent / n-butyl lithium / tetrahydrofuran / 3 h / -30 °C
2: mercuric chloride / methanol; tetrahydrofuran / 24 h / 130 °C
3: trifluoroacetic acid / 3 h / Ambient temperature
View Scheme
参考文献
Latey, P. P.; Deshpande, V. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 299 - 300
