2-(3-硝基苯基)-1,3,4-恶二唑合成路线 （共 10 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 16 h;
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
Location in patent: Paragraph 65 ;
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 1 h; Ambient temperature;
参考文献
Vincent,M.
Bulletin de la Societe Chimique de France, 1962 , p. 1587 - 1591
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 1 h; Ambient temperature;
参考文献
Vincent,M.
Bulletin de la Societe Chimique de France, 1962 , p. 1587 - 1591
反应条件
potassium alum
T=100°C; 6 h;
参考文献
Dabiri, Minoo; Salehi, Peyman; Baghbanzadeh, Mostafa; Bahramnejad, Mahboobeh
Monatshefte fur Chemie, 2007 , vol. 138, # 12 p. 1253 - 1255
反应条件
sulfuric acid; silica gel
T=20°C;
参考文献
Dabiri, Minoo; Salehi, Peyman; Baghbanzadeh, Mostafa; Zolfigol, Mohammad Ali; Bahramnejad, Mahboobeh
Synthetic Communications, 2007 , vol. 37, # 7 p. 1201 - 1209
反应条件
in benzene
0.0833333 h; Ambient temperature;
参考文献
Hussein, Ahmad Q.; El-Abadelah, Mustafa M.; Nazer, Musa Z.; Awadallah, Adel M.
Heterocycles, 1994 , vol. 38, # 5 p. 981 - 990
反应条件
1: 80 percent / 0.33 h / Heating
2: 85 percent / chloroacetic anhydride / toluene / 0.5 h
View Scheme
参考文献
El-Abadelah, M. M.; Nazer, M. Z.; Hussein, A. Q.; Awadallah, A. M.; Rademacher, P.; Woydt, M.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1229 - 1234
参考文献
Runti et al.
Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1649,1656, 1663
参考文献
Runti et al.
Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1649,1656, 1663
反应条件
1: H2 / Pd-C / methanol / 1 h / 760 Torr / Ambient temperature
2: Py / 4 h / 95 °C
3: aq. NaOH / Heating
View Scheme
参考文献
Vincent,M.
Bulletin de la Societe Chimique de France, 1962 , p. 1587 - 1591
