2-氯二苯并[b,f]氧杂卓-10(11H)-酮合成路线 （共 5 条）
参考文献
Harris, Terry W.; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 855 - 858
反应条件
sodium nitrite in hydrogenchloride; water; ethyl acetate; benzene
参考文献
Hoffmann-La Roche Inc.
Patent: US4032525 A1, 1977 ;
反应条件
1: 63 percent / K2CO3, Cu / 10 h / Heating
2: 1.) morpholine, sulfur, 2.) glacial acetic acid, conc. aq. HCl / 1.) reflux, 12 h, 2.) reflux, 8 h
3: 61 percent / polyphosphoric acid / 100 - 105 °C
View Scheme
参考文献
Harris, Terry W.; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 855 - 858
反应条件
1: 1.) morpholine, sulfur, 2.) glacial acetic acid, conc. aq. HCl / 1.) reflux, 12 h, 2.) reflux, 8 h
2: 61 percent / polyphosphoric acid / 100 - 105 °C
View Scheme
参考文献
Harris, Terry W.; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 855 - 858
反应条件
1: 63 percent / K2CO3, Cu / 10 h / Heating
2: 1.) morpholine, sulfur, 2.) glacial acetic acid, conc. aq. HCl / 1.) reflux, 12 h, 2.) reflux, 8 h
3: 61 percent / polyphosphoric acid / 100 - 105 °C
View Scheme
参考文献
Harris, Terry W.; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 855 - 858
