1-[(2-吡啶基)甲基]哌嗪合成路线 （共 9 条）
反应条件
hydrogenchloride; water in 1,4-dioxane; dichloromethane T=20°C; 5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 7 p. 1991 - 1996
反应条件
in water T=20°C; 16 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.
Patent: WO2008/153325 A1, 2008 ;
Location in patent: Page/Page column 76 ;
反应条件
potassium carbonate in acetonitrile 4 h; Heating;
参考文献
Ratilaincn, Jari; Airola, Karri; Kolehmaincn, Erkki; Rissanen, Kari
Chemische Berichte, 1997 , vol. 130, # 9 p. 1353 - 1359
Title/Abstract Full Text View citing articles Show Details
Loukiala, Satumari; Ratilainen, Jari; Airola, Karri; Valkonen, Jussi; Rissanen, Kari
Acta Chemica Scandinavica, 1998 , vol. 52, # 5 p. 593 - 602
反应条件
in water 18 h; Ambient temperature;
参考文献
Carceller, Elena; Merlos, Manuel; Giral, Marta; Almansa, Carmen; Bartroli, Javier; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2984 - 2997
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane; 1,2-dichloro-ethane / 20 h / 20 °C 2: hydrogenchloride; water / 1,4-dioxane; dichloromethane / 5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 7 p. 1991 - 1996
反应条件
1: 92 percent / SOCl2 / 4 h / Heating 2: 87 percent / K2CO3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 130, # 9 p. 1353 - 1359
Acta Chemica Scandinavica, , vol. 52, # 5 p. 593 - 602
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere 1.2: 4 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme
参考文献
WO2012/12314 A1, ;
WO 2012/012314 A1
反应条件
sodium hydroxide in tetrahydrofuran
24 h; Ambient temperature;
参考文献
Carceller, Elena; Merlos, Manuel; Giral, Marta; Almansa, Carmen; Bartroli, Javier; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2984 - 2997
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C;
参考文献
Kim, Dae-Kee; Lee, Ju Young; Kim, Jae-Sun; Ryu, Je-Ho; Choi, Jin-Young; Lee, Jun Won; Im, Guang-Jin; Kim, Tae-Kon; Seo, Jung Woo; Park, Hyun-Ju; Yoo, Jakyung; Park, Jung-Hyun; Kim, Tae-You; Bang, Yung-Jue
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5745 - 5751
