3-羟基-5-甲基-2-噻吩羧酸甲酯合成路线 (共 10 条)
反应条件
sulfuric acid in acetic acid
参考文献
Rossy, Phillip A.; Hoffmann, Werner; Mueller, Norbert
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 617 - 620
参考文献
Chemische Berichte, , vol. 89, p. 1907,1909
反应条件
1: methanol; hydrogen chloride 2: methanol. KOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 89, p. 1907,1909
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Heterocycles, , vol. 43, # 8 p. 1767 - 1770
反应条件
1: 66 percent / bromine, acetic acid / 16 h / Ambient temperature 2: 51 percent / potassium carbonate / acetone / 12 h / Heating View Scheme
参考文献
Mullican; Sorensen; Connor; Thueson; Kennedy; Conroy
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2186 - 2194
反应条件
bromine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
反应条件
bromine; acetic acid 16 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 7 p. 2186 - 2194
反应条件
1: 83 percent / K2CO3 / acetone / 12 h / Heating
2: 91 percent / 1N NaOH / 0.5 h / Heating
View Scheme
参考文献
Lissavetzky, Jaime; Manzanares, Ignacio
Heterocycles, 1996 , vol. 43, # 8 p. 1767 - 1770