反应条件
1: 1.) LiAlH4; 2.) HCl / 1.) diethyl ether, 8 h, reflux; 2.) 0 deg C, water
2: pyridine / 1 h / 0 °C
3: LiBr / acetone / 5 h / Heating
5: KOH / ethanol; H2O / 5 h / Heating
6: 75 percent / N2H4*H2O, KOH / bis-(2-hydroxy-ethyl) ether; methanol / 125 deg C, 6 h; 195 deg C, 3 h
View Scheme
参考文献
Dobner; Elsner; Nuhn
Pharmazie, 1989 , vol. 44, # 11 p. 758 - 760
