N,N-二甲基-3-苯基-3-羟基丙胺合成路线 （共 12 条）
反应条件
sodium tetrahydroborate in water
T=0 - 20°C;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
反应条件
diisobutylaluminium hydride in tetrahydrofuran; dichloromethane
2 h; Ambient temperature;
参考文献
Arava, Veera Reddy; Malreddy, Sashibhushan; Thummala, Sreenivasulu Reddy
Synthetic Communications, 2012 , vol. 42, # 24 p. 3545 - 3552,8
反应条件
lithium aluminium tetrahydride in diethyl ether
20 h; Heating;
参考文献
Suzuki, Kunio; Okano, Koji; Nakai, Kiyomitsu; Terao, Yoshiyasu; Sekiya, Minoru
Synthesis, 1983 , # 9 p. 723 - 725
反应条件
1: 84 percent / conc. aq. HCl / ethanol / 2 h / Heating
2: 92 percent / DIBAL-H / tetrahydrofuran; CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Miyano, Sotaro; Lu, Linda D.-L.; Viti, Steven M.; Sharpless, K. Barry
Journal of Organic Chemistry, 1985 , vol. 50, # 22 p. 4350 - 4360
反应条件
1: 81 percent / N-chlorosuccinimide / CCl4 / 4 h / Heating
2: LiAlH4 / diethyl ether / 20 h / Heating
View Scheme
参考文献
Suzuki, Kunio; Okano, Koji; Nakai, Kiyomitsu; Terao, Yoshiyasu; Sekiya, Minoru
Synthesis, 1983 , # 9 p. 723 - 725
反应条件
in acetonitrile
12 h; Heating; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Manninen, Kalle; Karjalainen, Aira
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 3 p. 190 - 195
参考文献
Fourneau
Chem. Zentralbl., 1907 , vol. 78, # II p. 1087
参考文献
Mannich; Heilner
Chemische Berichte, 1922 , vol. 55, p. 362
参考文献
Mannich; Heilner
Chemische Berichte, 1922 , vol. 55, p. 362
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
T=20°C;
参考文献
AAPA B.V.; HEERES, André; GROL, Cornelius Joannes; BORST, Marcus Leonardus Gerardus; WILLIGERS - Hogg, Sandra
Patent: WO2014/46544 A1, 2014 ;
Location in patent: Page/Page column 21; 36 ;
