2’-O-甲基-5-甲基尿苷合成路线 （共 28 条）
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol T=45°C; P=2250.2 Torr;
参考文献
Martin
Helvetica Chimica Acta, 1995 , vol. 78, # 2 p. 486 - 504
反应条件
sodium hydrogencarbonate; trimethyl orthoformate in methanol T=150°C; P=10343 Torr; 42 h;
参考文献
Ross, Bruce S.; Springer, Robert H.; Tortorici, Zeb; Dimock, Stuart
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1641 - 1643
反应条件
ammonium hydroxide in methanol 24 h;
参考文献
Ross; Springer; Vasquez; Andrews; Cook; Acevedo
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 765 - 769
反应条件
hydrogenchloride in methanol; dichloromethane 0.75 h; Ambient temperature;
参考文献
Lewis; Revankar; Hogan
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1309 - 1316
反应条件
1: 1.) cc. H2SO4, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C 2: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 3: pyridine, 4-(dimethylamino)-pyridine / 17 h 4: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 5: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 6: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 7: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 8: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 9: 30percent NaOMe / methanol / Ambient temperature; pH 11 10: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: pyridine, 4-(dimethylamino)-pyridine / 17 h 2: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 3: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 4: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 5: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 6: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 7: 30percent NaOMe / methanol / Ambient temperature; pH 11 8: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 2: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 3: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 4: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 5: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 6: 30percent NaOMe / methanol / Ambient temperature; pH 11 7: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 2: pyridine, 4-(dimethylamino)-pyridine / 17 h 3: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 4: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 5: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 6: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 7: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 8: 30percent NaOMe / methanol / Ambient temperature; pH 11 9: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 2: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 3: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 4: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 5: 30percent NaOMe / methanol / Ambient temperature; pH 11 6: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: 30percent NaOMe / methanol / Ambient temperature; pH 11 4: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
