3-(吲哚-3-基)丙酸甲酯合成路线 （共 23 条）
反应条件
in diethyl ether
T=20°C; 1 h;
参考文献
Thompson, Andrew M.; Fry, David W.; Kraker, Alan J.; Denny, William A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 598 - 609
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130°C; RefluxGreen chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
0.25 h; Heating;
参考文献
Barton, Derek H. R.; Bringmann, Gerhard; Motherwell, Wiliam B.
Synthesis, 1980 , # 1 p. 68 - 70
反应条件
layered double hydroxide - supported L-methionine
T=180°C; 6 h; Autoclave; chemoselective reaction;
参考文献
Dhakshinamoorthy, Amarajothi; Sharmila, Alagarsamy; Pitchumani, Kasi
Chemistry - A European Journal, 2010 , vol. 16, # 4 p. 1128 - 1132
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in chloroform
24 h; Reflux;
参考文献
Gonzalez, Alfredo; Perez, Daniel; Puig, Carles; Ryder, Hamish; Sanahuja, Jordi; Sole, Laia; Bach, Jordi
Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2750 - 2753
反应条件
1: POCl3, N(C2H5)3 / CH2Cl2 / 4 h / Ambient temperature
2: 72 percent / AIBN, tri-n-butyltin hydride / benzene / 0.25 h / Heating
View Scheme
参考文献
Barton, Derek H. R.; Bringmann, Gerhard; Motherwell, Wiliam B.
Synthesis, 1980 , # 1 p. 68 - 70
反应条件
1: 1.) Amberlite resin IR-45 / 1.) CHCl3, 2.) ether, 2 h
2: POCl3, N(C2H5)3 / CH2Cl2 / 4 h / Ambient temperature
3: 72 percent / AIBN, tri-n-butyltin hydride / benzene / 0.25 h / Heating
View Scheme
参考文献
Barton, Derek H. R.; Bringmann, Gerhard; Motherwell, Wiliam B.
Synthesis, 1980 , # 1 p. 68 - 70
参考文献
Hasegawa, Masakazu; Tabata, Mutsuko; Satoh, Keiichi; Yamada, Fumio; Somei, Masanori
Heterocycles, 1996 , vol. 43, # 11 p. 2333 - 2342
反应条件
anhydrous copper acetate in methanol
T=20°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Shimizu, Ryo; Egami, Hiromichi; Nagi, Tatsuya; Chae, Jungha; Hamashima, Yoshitaka; Sodeoka, Mikiko
Tetrahedron Letters, 2010 , vol. 51, # 45 p. 5947 - 5949
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Phillips; Cohen
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2023 - 2030
