alpha,alpha-二甲基环己烷乙胺合成路线 （共 8 条）
反应条件
acetic acid; thiourea in ethanol
T=100°C; 16 h;
参考文献
PFIZER INC.; HUMPHRIES, Paul, Stuart; PRICE, David, Anthony
Patent: WO2010/103429 A1, 2010 ;
Location in patent: Page/Page column 49-50 ;
WO 2010/103429 A1
反应条件
hydrogen; platinum(IV) oxide in acetic acid
参考文献
Gadekar,S.M. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 4 p. 811 - 814
反应条件
acetic acid; platinum
Hydrogenation;
参考文献
Zenitz; Macks; Moore
Journal of the American Chemical Society, 1948 , vol. 70, p. 955
反应条件
1: aqueous hydriodic acid; phosphorus
2: platinum; acetic acid / Hydrogenation
View Scheme
参考文献
Zenitz; Macks; Moore
Journal of the American Chemical Society, 1948 , vol. 70, p. 955
反应条件
sodium hydroxide in ethylene glycol
Heating;
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
反应条件
1: (i) H2SO4, AcOH, (ii) /BRN= 2345931/
2: aq. NaOH / ethane-1,2-diol / Heating
View Scheme
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 635680/
2: (i) H2SO4, AcOH, (ii) /BRN= 2345931/
3: aq. NaOH / ethane-1,2-diol / Heating
View Scheme
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
反应条件
1: aqueous potassium hypobromite
2: aqueous hydrochloric acid
View Scheme
参考文献
Mentzer; Buu-Hoi; Cagniant
Bulletin de la Societe Chimique de France, 1942 , vol. <5> 9, p. 813,816
