1-环己基-2-甲基-2-丙醇合成路线 （共 9 条）
反应条件
in tetrahydrofuran; diethyl ether
T=0°C;
参考文献
PFIZER INC.; HUMPHRIES, Paul, Stuart; PRICE, David, Anthony
Patent: WO2010/103429 A1, 2010 ;
Location in patent: Page/Page column 42-43 ;
WO 2010/103429 A1
参考文献
Takasago International Corporation
Patent: US6489273 B1, 2002 ;
反应条件
1: hydrogen; palladium
View Scheme
参考文献
Wallach
Justus Liebigs Annalen der Chemie, 1912 , vol. 394, p. 372
Chem. Zentralbl., 1908 , vol. 79, # I p. 637,639
反应条件
1: sodium ethylate / 0 °C
2: hydrogen; palladium
View Scheme
参考文献
Wallach
Justus Liebigs Annalen der Chemie, 1912 , vol. 394, p. 372
Chem. Zentralbl., 1908 , vol. 79, # I p. 637,639
反应条件
(i) Mg, Et2O, (ii) /BRN= 635680/; Multistep reaction;
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
参考文献
Wallach
Justus Liebigs Annalen der Chemie, 1912 , vol. 394, p. 372
Chem. Zentralbl., 1908 , vol. 79, # I p. 637,639
参考文献
Peters,J.A.; van Bekkum,H.
Recueil des Travaux Chimiques des Pays-Bas, 1973 , vol. 92, p. 379 - 392
反应条件
1: (i) H2SO4, AcOH, (ii) /BRN= 2345931/
2: LiAlH4 / diethyl ether / Heating
View Scheme
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
反应条件
1: (i) H2SO4, AcOH, (ii) /BRN= 2345931/
2: aq. NaOH / ethane-1,2-diol / Heating
View Scheme
参考文献
Data; Skibbe; Kerley; Weaver
Journal of pharmaceutical sciences, 1966 , vol. 55, # 1 p. 38 - 43
