4-羟基-6-苯基吡喃-2-酮合成路线 （共 31 条）
反应条件
T=25 - 150°C; P=3 Torr; 0.75 h;
参考文献
Narasimhan; Ammanamanchi
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 3945 - 3947
反应条件
trifluoroacetic anhydride in diethyl ether
T=0°C; 2 h;
参考文献
Tanyeli, Cihangir; Tarhan, Okan
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2453 - 2460
反应条件
in toluene
0.5 h; Heating;
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Hall, C. Dennis; Suzuki, Kazuyuki
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4854 - 4856
反应条件
in diethyl ether
T=-78 - 20°C;
参考文献
Prasad; Para; Tummino; Ferguson; McQuade; Lunney; Rapundalo; Batley; Hingorani; Domagala; Gracheck; Bhat; Liu; Baldwin; Erickson; Sawyer
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 898 - 905
反应条件
type III polyketide synthase RppA from S. griseus; 2-hydroxyethanethiol in various solvent(s)
T=37°C; pH=7.5; 2 h;
参考文献
Jeong, Jae-Cheol; Srinivasan, Aravind; Grueschow, Sabine; Bach, Horacio; Sherman, David H.; Dordick, Jonathan S.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 64 - 65
参考文献
Tominaga, Yoshinori; Ushirogochi, Atsuyuki; Matsuda, Yoshiro
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1557 - 1567
反应条件
AuNTf2(SPhos); acetic acid
T=20°C; 24 h; Inert atmosphere;
参考文献
Chaladaj, Wojciech; Corbet, Matthieu; Fuerstner, Alois
Angewandte Chemie - International Edition, 2012 , vol. 51, # 28 p. 6929 - 6933
反应条件
Dithiothreitol; chalcone synthase, immobilized onto Ni-nitrilotriacetic acid agarose; malonyl-CoA synthetase, immobilized onto glutathione-sepharose; disodium malonate; ATP disodium salt; Coenzyme A; magnesium chloride
T=22°C; pH=7.5; 72 h; Tris-HCl bufferEnzymatic reaction;
参考文献
Kim, Moon I.I.; Kwon, Seok Joon; Dordick, Jonathan S.
Organic Letters, 2009 , vol. 11, # 17 p. 3806 - 3809
反应条件
1: 86 percent / potassium hydroxide / ethanol / 0.5 h / 20 °C
2: 92 percent / TFA / various solvent(s) / 2 h / 0 °C
View Scheme
参考文献
Schmidt, Dietmar; Conrad, Juergen; Klaiber, Iris; Beifuss, Uwe
Chemical Communications, 2006 , # 45 p. 4732 - 4734
反应条件
1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.17 h / 0 °C
1.2: 77 percent / tetrahydrofuran; hexane / 3 h / 0 °C
2.1: 86 percent / potassium hydroxide / ethanol / 0.5 h / 20 °C
3.1: 92 percent / TFA / various solvent(s) / 2 h / 0 °C
View Scheme
参考文献
Schmidt, Dietmar; Conrad, Juergen; Klaiber, Iris; Beifuss, Uwe
Chemical Communications, 2006 , # 45 p. 4732 - 4734
