(3beta,20S)-4,4,20-三甲基-21-[[三(异丙基l)硅烷基]氧基]-孕甾-5-烯-3-醇3-苯甲酸酯合成路线 （共 3 条）
→
64284-64-6(3R,5S,10S,13S,17S)-4,4,10,13-四甲基-17-[(2R)-6-甲基庚-5-烯-2-基]-1,2,3,5,6,7,11,12,16,17-十氢环戊烯并[a]菲-3-醇
反应条件
1: 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione / benzene; hexane / 0.5 h / 70 °C
2: 2,4,6-trimethylpyridine / toluene / 2 h / Heating
3: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4: 72 percent / pyridine; 4-(dimethylamino)pyridine / 2 h / 50 °C
5: 100 percent / Li2CuCl3 / tetrahydrofuran / -30 - 20 °C
6: 69 percent / H2SO4 / dioxane / 70 h / Heating
View Scheme
参考文献
Blume, Thorsten; Guttzeit, Marc; Kuhnke, Joachim; Zorn, Ludwig
Organic Letters, 2003 , vol. 5, # 11 p. 1837 - 1839
反应条件
Multi-step reaction with 4 steps 1: imidazole / CH2Cl2 / 4 h / 20 °C2: t-BuOK / 2-methyl-propan-2-ol / 0.5 h / 20 °C3: LiAlH4 / tetrahydrofuran / 0.5 h / 20 °C4: pyridine / 1 h / 0 °C
参考文献
Blume, Thorsten; Guttzeit, Marc; Kuhnke, Joachim; Zorn, Ludwig Organic Letters, 2003 , vol. 5, # 11 p. 1837 - 1839
反应条件
Multi-step reaction with 3 steps 1: 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione / benzene; hexane / 0.5 h / 70 °C2: 2,4,6-trimethylpyridine / toluene / 2 h / Heating3: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
参考文献
Blume, Thorsten; Guttzeit, Marc; Kuhnke, Joachim; Zorn, Ludwig Organic Letters, 2003 , vol. 5, # 11 p. 1837 - 1839
