2-[6-(2-羟基-2-苯基-乙基)-1-甲基-2-哌啶基]-1-苯基-乙醇合成路线 (共 2 条)
反应条件
Pd(sparteine)Cl2; 6-methoxy-2-naphthol sodium salt; oxygen; (-)-sparteine in chloroform T=35°C; 48 h; Molecular sieve; optical yield given as percent ee;
参考文献
Krishnan, Shyam; Bagdanoff, Jeffrey T.; Ebner, David C.; Ramtohul, Yeeman K.; Tambar, Uttam K.; Stoltz, Brian M.
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13745 - 13754
反应条件
1: 92 percent / (S)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; Na2SO4 / CDCl3 / 48 h / 20 °C 2: CrO3; H2SO4 / acetone / 1 h / 20 °C 3: aq. HCl / methanol / Heating View Scheme
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin
Organic Letters, 2007 , vol. 9, # 17 p. 3237 - 3240