1.1: Aliquatreg; 336; potassium carbonate / water; toluene / 0.75 h / 20 °C / Inert atmosphere 1.2: 16 h / 85 °C / Inert atmosphere 2.1: potassium hydroxide / tetrahydrofuran; water; dimethyl sulfoxide / 4 h / 80 °C 2.2: 20 °C View Scheme

potassium hydroxide in acetone 0.25 h; Inert atmosphereReflux;

potassium hydroxide in acetone 0.25 h; Inert atmosphereReflux;

1: With sodium hydride in N,N-dimethyl-formamide T=0°C; 2: With iodine; nitric acid; acetic acid Reflux;

1.1: acetic acid; potassium iodide; KIO3 / 24 h / 80 °C / |Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / |Inert atmosphere 2.2: 4 h / 0 °C / |Inert atmosphere View Scheme