4-甲氧基吡啶-2-氨甲酸叔丁酯合成路线 （共 5 条）
反应条件
1: 4-methoxy-pyridin-2-ylamine With lithium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C;
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; JONES, Phillip, G.; MALCOLM, Scott
Patent: WO2013/192273 A1, 2013 ;
Location in patent: Paragraph 00349 ;
反应条件
1: t-BuONO, TFAA / tetrahydrofuran / 0.5 h / 0 °C 2: toluene / 1.) reflux, 1 h, 2.) reflux, 10 h View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
反应条件
1: 93 percent / NH2NH2 / methanol / 6 h / Heating 2: t-BuONO, TFAA / tetrahydrofuran / 0.5 h / 0 °C 3: toluene / 1.) reflux, 1 h, 2.) reflux, 10 h View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
反应条件
in toluene 1.) reflux, 1 h, 2.) reflux, 10 h;
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
反应条件
trifluoroacetic anhydride in toluene 5 h; Heating;
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
