1-(6-羟基吡唑并[1,5-b]吡嗪-3-基)乙酮合成路线 （共 2 条）
反应条件
hydrogen iodide in water
T=90°C; 12 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/35588 A1, 2004 ;
Location in patent: Page 62 ;
WO 2004/035588 A1
反应条件
1: 3-hydroxypyridazine With potassium hydrogencarbonate; hydroxylamine-o-sulphonic acid
pH=5;
2: methyl ethynyl ketone in dichloromethane
T=20°C;
参考文献
Tavares, Francis X.; Boucheron, Joyce A.; Dickerson, Scott H.; Griffin, Robert J.; Preugschat, Frank; Thomso, Stephen A.; Wang, Tony Y.; Zhouf, Hui-Qiang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4716 - 4730
