1-(6-甲氧基吡唑并[1,5-b]吡嗪-3-基)乙酮合成路线 （共 4 条）
反应条件
1: 3-methoxypyridazine hydrochloride With hydroxylamine-o-sulphonic acid in water
T=70°C; pH=8.0; 1 h;
2: methyl ethynyl ketone With potassium hydroxide in dichloromethane; water
T=0 - 20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/35588 A1, 2004 ;
Location in patent: Page 59-60 ;
WO 2004/035588 A1
反应条件
1: 3-methoxypyridazine With potassium hydrogencarbonate; hydroxylamine-o-sulphonic acid
pH=8.0;
2: methyl ethynyl ketone in dichloromethane
T=20°C;
参考文献
Tavares, Francis X.; Boucheron, Joyce A.; Dickerson, Scott H.; Griffin, Robert J.; Preugschat, Frank; Thomso, Stephen A.; Wang, Tony Y.; Zhouf, Hui-Qiang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4716 - 4730
反应条件
potassium hydroxide in dichloromethane; water
参考文献
Stevens, Kirk L.; Reno, Michael J.; Alberti, Jennifer B.; Price, Daniel J.; Kane-Carson, Laurie S.; Knick, Victoria B.; Shewchuk, Lisa M.; Hassell, Anne M.; Veal, James M.; Davis, Stephen T.; Griffin, Robert J.; Peel, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 21 p. 5758 - 5762
反应条件
hydrogen iodide in water
T=90°C; 12 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/35588 A1, 2004 ;
Location in patent: Page 62 ;
WO 2004/035588 A1
