1-苄基-1,4-二氮杂环庚-5-酮合成路线 （共 5 条）
反应条件
1: With sodium azide; sulfuric acid; acetic acid T=0 - 5°C; 27 h; 2: With sodium hydroxide in water
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1591443 A1, 2005 ;
Location in patent: Page/Page column 72 ;
反应条件
DMEG; triethylamine in water; acetonitrile T=20°C; Rearrangement; 16 h;
参考文献
Isobe, Toshio; Ishikawa, Tsutomu
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 5832 - 5835
反应条件
hydrogen; palladium dihydroxide in ethanol T=20°C;
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 124; 125 ;
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Dickerman; Besozzi
Journal of Organic Chemistry, 1954 , vol. 19, p. 1855,1856, 1859
反应条件
1: H2 / Pd(OH)2 / ethanol / 20 °C 2: CH2Cl2 / 20 °C View Scheme
参考文献
Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Caldwell, Charles G.; Chen, Ping; Hagmann, William K.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Kelly, Theresa M.; Grant, Stephan K.; Wong, Kenny K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5907 - 5911
