cesium fluoride in acetonitrile T=20°C; 12 h;

1: in tetrahydrofuran; diethyl ether T=0°C; 0.5 h; 2: With hydrogenchloride; water in water T=0 - 20°C;

perchloric acid in acetic acid 0.166667 h; Reflux;

dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate in toluene T=180°C; Mizoroki-Heck cyclization; 0.5 h; Inert atmosphereMicrowave irradiation;

tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine in 1,4-dioxane T=110°C; Mizoroki-Heck cyclization; 2.5 h; Inert atmosphere;

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 6 h / 110 °C / Inert atmosphere View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Reflux 2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 6 h / 110 °C / Inert atmosphere View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Reflux 2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 6 h / 110 °C / Inert atmosphere View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine / 1,4-dioxane / 2.5 h / 110 °C / Inert atmosphere View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Reflux 2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine / 1,4-dioxane / 2.5 h / 110 °C / Inert atmosphere View Scheme