3,4-二甲氧基-2-硝基苯甲醛合成路线 （共 21 条）
反应条件
1: acetic acid anhydride 2: ammonia; ferrosulfate 3: Diazotization.Einw. molekularen Kupferpulvers in Schwefelsaeure 4: 300 Torr / durch Destillieren 5: glacial acetic acid; concentrated hydriodic acid / 130 - 135 °C View Scheme
参考文献
Pschorr; Sumuleanu
Chemische Berichte, 1900 , vol. 33, p. 1822
反应条件
1: Raney nickel; ethyl acetate / Hydrogenation 2: sodium ethylate; ethanol 3: pyridine hydrochloride / 200 - 220 °C View Scheme
参考文献
Ried et al.
Chemische Berichte, 1952 , vol. 85, p. 204,212
参考文献
Insole, Joan M.
Journal of Chemical Research, Miniprint, 1990 , # 12 p. 2831 - 2867
反应条件
caesium carbonate; sodium iodide in N,N-dimethyl-formamide
T=20 - 80°C; 25 h; Inert atmosphere;
参考文献
Turkman, Nashaat; Shavrin, Aleksander; Ivanov, Roman A.; Rabinovich, Brian; Volgin, Andrei; Gelovani, Juri G.; Alauddin, Mian M.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5698 - 5707
反应条件
potassium hydroxide
T=100°C; unter Druck;
参考文献
Pschorr; Sumuleanu
Chemische Berichte, 1899 , vol. 32, p. 3407
反应条件
1: acetic acid 4-formyl-2-methoxy-3-nitro-phenyl ester With sodium hydroxide in water
T=60°C; 1.5 h;
2: methyl iodide With potassium carbonate in water; acetone
1.5 h; Reflux;
参考文献
Wada, Yasufumi; Harayama, Yu; Kamimura, Daigo; Yoshida, Masako; Shibata, Tomoyuki; Fujiwara, Kousaku; Morimoto, Koji; Fujioka, Hiromichi; Kita, Yasuyuki
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4959 - 4976
反应条件
sodium hydroxide; sodium carbonate; dimethyl sulfate in hexane; water; ethyl acetate; toluene
参考文献
Pfizer Inc.
Patent: US4287341 A1, 1981 ;
反应条件
1: nitric acid / 3 h
2: potassium hydroxide / H2O / 0.17 h / Heating
3: sodium hydroxide / ethanol; H2O / 3 h / 50 °C
View Scheme
参考文献
Rege, Pankaj D.; Tian, Yuan; Corey
Organic Letters, 2006 , vol. 8, # 14 p. 3117 - 3120
反应条件
1: potassium hydroxide / H2O / 0.17 h / Heating
2: sodium hydroxide / ethanol; H2O / 3 h / 50 °C
View Scheme
参考文献
Rege, Pankaj D.; Tian, Yuan; Corey
Organic Letters, 2006 , vol. 8, # 14 p. 3117 - 3120
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
2.1: nitric acid / ethylene glycol / 3 h / 5 °C
2.2: 0.17 h / 100 °C
3.1: sodium hydroxide / ethanol; water / 3 h / 50 °C / Cooling with ice
View Scheme
参考文献
De Luca, Laura; De Grazia, Sara; Ferro, Stefania; Gitto, Rosaria; Christ, Frauke; Debyser, Zeger; Chimirri, Alba
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 756 - 764
