吡啶并[3’,2’:4,5]噻吩并[3,2-d]嘧啶-4(3h)-酮合成路线 （共 6 条）
反应条件
T=135 - 190°C; Cyclization; 5 h;
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
1.1: NaH / dimethylsulfoxide / 25 °C
1.2: 89 percent / dimethylsulfoxide / 3 h / 25 °C
2.1: 73 percent / 5 h / 135 - 190 °C
View Scheme
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
acetic acid
T=150°C; 0.166667 h; Microwave irradiation;
参考文献
Zhao, Chunlin; Tovar, Christian; Yin, Xuefeng; Xu, Qui; Todorov, Ivan T.; Vassilev, Lyubomir T.; Chen, Li
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 319 - 323
参考文献
Dunn, A. D.; Norrie, R.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 85 - 89
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane
T=85°C; Substitution; 2 h;
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
1: POCl3 / pyridine
2: H2 / Pd-C / ethanol
3: N2H4*H2O / ethanol
View Scheme
参考文献
Schneller; Clough
Journal of Heterocyclic Chemistry, 1974 , vol. 11, # 6 p. 975 - 977
