2-氧代-2-(吡啶-2-基)乙酸乙酯合成路线 （共 8 条）
反应条件
1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / toluene / 70 °C / |Inert atmosphere 2: sodium tetrahydroborate / ethanol / 2.5 h / 15 - 30 °C / |Inert atmosphere; |Large scale 3: pyridine / acetonitrile / 1.25 h / 10 - 18 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / toluene / 70 °C / |Inert atmosphere 2: sodium tetrahydroborate / ethanol / 2.5 h / 15 - 30 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
4,4'-diamino-stilbene-2,2'-disulphonic acid; sodium hydrogencarbonate in ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6455532 B1, 2002 ;
US 6455532 B1
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in toluene T=70°C; Inert atmosphere;
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / toluene / 70 °C / |Inert atmosphere 2: sodium tetrahydroborate / ethanol / 2.5 h / 15 - 30 °C / |Inert atmosphere; |Large scale 3: pyridine / acetonitrile / 1.25 h / 10 - 18 °C / |Inert atmosphere; |Large scale 4: ammonia / water / 17 h / 20 - 25 °C / |Inert atmosphere View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
isopropylmagnesium chloride
T=34°C; Inert atmosphere;
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
in benzene
0.5 h; Ambient temperature;
参考文献
Yamamoto; Ouchi; Tanaka
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 6 p. 1028 - 1030
参考文献
Powell, Paul; Sosabowski, Michael H.
Journal of Chemical Research, Miniprint, 1995 , # 10 p. 2422 - 2434
