1.1: Ni(cod)2; PPh3; i-Bu2-ALAC / toluene / 2 h / 0 °C 2.1: imidazole / dimethylformamide / 7 h / 20 °C 3.1: O3; O2 / CH2Cl2 / -78 °C 3.2: PPh3 / CH2Cl2 / 12 h / 20 °C 4.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C 4.2: tetrahydrofuran / 0.25 h 5.1: methanol; diethyl ether / 0 °C 6.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C 7.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 8.1: Dowex50W / methanol / 0.5 h / 50 °C 9.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 10.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 11.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 12.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 13.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 13.2: tetrahydrofuran / 1 h 14.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 15.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 16.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: imidazole / dimethylformamide / 7 h / 20 °C 2.1: O3; O2 / CH2Cl2 / -78 °C 2.2: PPh3 / CH2Cl2 / 12 h / 20 °C 3.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C 3.2: tetrahydrofuran / 0.25 h 4.1: methanol; diethyl ether / 0 °C 5.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C 6.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 7.1: Dowex50W / methanol / 0.5 h / 50 °C 8.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 9.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 10.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 11.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 12.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 12.2: tetrahydrofuran / 1 h 13.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 14.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 15.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: Dess-Martin reagent / CH2Cl2 / 1 h / 0 °C 2.1: Ni(cod)2; PPh3; i-Bu2-ALAC / toluene / 2 h / 0 °C 3.1: imidazole / dimethylformamide / 7 h / 20 °C 4.1: O3; O2 / CH2Cl2 / -78 °C 4.2: PPh3 / CH2Cl2 / 12 h / 20 °C 5.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C 5.2: tetrahydrofuran / 0.25 h 6.1: methanol; diethyl ether / 0 °C 7.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C 8.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 9.1: Dowex50W / methanol / 0.5 h / 50 °C 10.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 11.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 12.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 13.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 14.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 14.2: tetrahydrofuran / 1 h 15.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 16.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 17.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C 2.1: Dess-Martin reagent / CH2Cl2 / 1 h / 0 °C 3.1: Ni(cod)2; PPh3; i-Bu2-ALAC / toluene / 2 h / 0 °C 4.1: imidazole / dimethylformamide / 7 h / 20 °C 5.1: O3; O2 / CH2Cl2 / -78 °C 5.2: PPh3 / CH2Cl2 / 12 h / 20 °C 6.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C 6.2: tetrahydrofuran / 0.25 h 7.1: methanol; diethyl ether / 0 °C 8.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C 9.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 10.1: Dowex50W / methanol / 0.5 h / 50 °C 11.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 12.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 13.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 14.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 15.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 15.2: tetrahydrofuran / 1 h 16.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 17.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 18.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: O3; O2 / CH2Cl2 / -78 °C 1.2: PPh3 / CH2Cl2 / 12 h / 20 °C 2.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C 2.2: tetrahydrofuran / 0.25 h 3.1: methanol; diethyl ether / 0 °C 4.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C 5.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 6.1: Dowex50W / methanol / 0.5 h / 50 °C 7.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 8.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 9.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 10.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 11.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 11.2: tetrahydrofuran / 1 h 12.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 13.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 14.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: DMAP; pyridine / CH2Cl2 / 2 h / 20 °C 2.1: Dowex50W / methanol / 0.5 h / 50 °C 3.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 4.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 5.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 6.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 7.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 7.2: tetrahydrofuran / 1 h 8.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 9.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 10.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: Dowex50W / methanol / 0.5 h / 50 °C 2.1: Et3N; DMAP / CH2Cl2 / 36 h / 20 °C 3.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 4.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 5.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 6.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 6.2: tetrahydrofuran / 1 h 7.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 8.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 9.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 2: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 3: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 2: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: pyridinium p-toluenesulfonate / CH2Cl2 / 12 h / 20 °C 2.1: tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 0 °C 3.1: PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 0 °C 4.1: NaH / tetrahydrofuran / 0.08 h / 20 °C 4.2: tetrahydrofuran / 1 h 5.1: LiAlH4; (S)-binaphthol / tetrahydrofuran; ethanol / 1 h / -78 °C 6.1: aq. AcOH / tetrahydrofuran / 2.5 h / 40 °C 7.1: 1.0 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme