4-氯-1H-吡咯并[2,3-b]吡啶合成路线 （共 78 条）
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dimethyl-ether; n-heptane 2: With trichlorophosphate T=85°C; 3: With sodium hydroxide in water pH=10;
参考文献
Shin, Heerim; Kim, Mi Kyoung; Chong, Youhoon
Chemical and Pharmaceutical Bulletin, 2014 , vol. 62, # 3 p. 217 - 220
反应条件
methanesulfonyl chloride in N,N-dimethyl-formamide T=50 - 73°C; 2 h;
参考文献
INCYTE CORPORATION
Patent: WO2006/69080 A2, 2006 ;
Location in patent: Page/Page column 35 ;
WO 2006/069080 A2
反应条件
trichlorophosphate T=20 - 90°C; 18 h;
参考文献
El-Gamal, Mohammed I.; Oh, Chang-Hyun
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 5 p. 1571 - 1576
反应条件
in N,N-dimethyl-formamide T=50 - 72°C;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2007/125325 A1, 2007 ;
Location in patent: Page/Page column 86 ;
WO 2007/125325 A1
反应条件
trichlorophosphate in water
参考文献
US6878714 B2, ;
US 6878714 B2
反应条件
sodium t-butanolate in 1,4-dioxane T=80°C; 3 h; Inert atmosphere;
参考文献
Chaulet, Charlotte; Croix, Cecile; Basset, Joan; Pujol, Maria-Dolores; Viaud-Massuard, Marie-Claude
Synlett, 2010 , # 10 p. 1481 - 1484
反应条件
1: With triethylamine in N,N-dimethyl-formamide 6 h; Cooling with ice; 2: With sodium hydrogencarbonate in water; N,N-dimethyl-formamide
参考文献
EP2103620 A1, ;
Page/Page column 70 ;
反应条件
in trichlorophosphate
参考文献
Liang, Congxin; Sun, Li; Wei, Chung Chen; Tang, Peng Cho; McMahon, Gerald; Hirth, Klaus Peter; Cui, Jingrong
Patent: US2002/183319 A1, 2002 ;
US 20020183319 A1
反应条件
1: With sulfuric acid; isopentyl nitrite in acetic acid T=12°C; 3 h; 2: With hydrogenchloride; copper(l) chloride in water; acetic acid T=50 - 90°C; 0.5 h; 3: With sodium hydroxide in water; acetic acid pH=> 7; Product distribution / selectivity;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/39796 A1, 2004 ;
Location in patent: Page/Page column 66 ;
WO 2004/039796 A1
反应条件
1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene 2: n-butyllithium; iodine / tetrahydrofuran View Scheme
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
