4-(4-甲基哌嗪基)-1,2-苯二胺合成路线 （共 12 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; ethyl acetate 2 h; Ambient temperature;
参考文献
Peter MacCallum Cancer Institute
Patent: EP2044938 A2, 2009 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 90 percent / 2 h / 130 - 140 °C 2: H2 / Raney Ni / dioxane / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 23, p. 576 - 580
Zhurnal Organicheskoi Khimii, , vol. 23, # 3 p. 637 - 642
反应条件
1: 60 percent / K2CO3 / dimethylformamide / 4.5 h / Heating 2: H2 / 10percent Pd/C / methanol / 1.25 h / Ambient temperature View Scheme
参考文献
Journal of medicinal chemistry, , vol. 39, # 24 p. 4804 - 4809
反应条件
1: 1.98 kg / aq. ethanol / 2 h 2: 85.4 percent / KOt-Bu / tetrahydrofuran; toluene / 2 h / 17 - 30 °C View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
Na2S2O5 in ethanol; water 6 h; Reflux;
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
反应条件
in nitrobenzene T=145°C;
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
in nitrobenzene T=145°C;
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
in nitrobenzene T=145°C;
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
1: 1.171 g / AcOH / 12 h / 55 °C 2: H2 / 10percent Pd/C / methanol / 1.25 h / Ambient temperature 3: 80 percent / mol. sieves / nitrobenzene; toluene / 36 h / 98 - 100 °C View Scheme
参考文献
Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis
Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809
反应条件
acetic acid 3 h; Heating; Yield given;
参考文献
Sokolova, N. Yu.; Kuznetsov, V. A.; Garabadzhiu, A. V.; Ginzburg, L. F.; Dobrynin, Ya. V.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 1 p. 40 - 42
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 1 p. 31 - 33
