1-氮杂螺[4.5]-2-癸酮合成路线 （共 21 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=25°C; 15 h;
参考文献
Mimura; Hayashida; Nomiyama; Ikegami; Iida; Tamura; Hiyama; Ohishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 11 p. 1971 - 1986
反应条件
trimethylsilyl iodide in chloroform
T=60°C; 15 h;
参考文献
Miller, R. D.; Goelitz, P.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1616 - 1618
反应条件
ammonia; sodium in ethanol
T=-78°C;
参考文献
Ito; Yamazaki; Kibayashi
Synlett, 2001 , # 10 p. 1506 - 1510
反应条件
tri-ruthenium(0)dodecacarbonyl; carbon monoxide; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide
T=150°C; 4 h; Autoclave;
参考文献
Armanino, Nicolas; Carreira, Erick M.
Journal of the American Chemical Society, 2013 , vol. 135, # 18 p. 6814 - 6817
反应条件
hydrogenchloride; zinc in ethanol
16 h; Heating;
参考文献
Bryce, Martin R.; Gardiner, John M.; Horton, Paul J.; Smith, Susan A.
Journal of Chemical Research, Miniprint, 1989 , # 1 p. 116 - 124
反应条件
1: 85 percent / Triton-B / tetrahydrofuran; 2-methyl-propan-2-ol / 48 h / 20 °C
2: 75 percent / conc. HCl, activated Zn dust / ethanol / 16 h / Heating
View Scheme
参考文献
Bryce, Martin R.; Gardiner, John M.; Horton, Paul J.; Smith, Susan A.
Journal of Chemical Research, Miniprint, 1989 , # 1 p. 116 - 124
反应条件
1.1: 89 percent / di-tert-butylhyponitrite; PhSO2N3; (Bu3Sn)2 / benzene / Heating
2.1: H2 / Pd/C / ethanol / 36 h / 20 °C / 22501.8 Torr
2.2: 86 percent / Et3N / ethanol / 4 h / Heating
View Scheme
参考文献
Panchaud, Philippe; Ollivier, Cyril; Renaud, Philippe; Zigmantas, Sarunas
Journal of Organic Chemistry, 2004 , vol. 69, # 8 p. 2755 - 2759
反应条件
1: 48 h / Heating
2: 1.) disiamylborane, 2.) H2O2 / 1.) THF, 0 deg C, then 25 deg C, 0.4 h, 2.) 0 deg C, aq. NaOH, 50 deg C, 1 h
3: Jones reagent / acetone / 0.17 h / 25 °C
4: 90 percent / trimethylsilyl iodide / CHCl3 / 15 h / 60 °C
View Scheme
参考文献
Miller, R. D.; Goelitz, P.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1616 - 1618
反应条件
1: 1.) disiamylborane, 2.) H2O2 / 1.) THF, 0 deg C, then 25 deg C, 0.4 h, 2.) 0 deg C, aq. NaOH, 50 deg C, 1 h
2: Jones reagent / acetone / 0.17 h / 25 °C
3: 90 percent / trimethylsilyl iodide / CHCl3 / 15 h / 60 °C
View Scheme
参考文献
Miller, R. D.; Goelitz, P.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1616 - 1618
反应条件
1: Jones reagent / acetone / 0.17 h / 25 °C
2: 90 percent / trimethylsilyl iodide / CHCl3 / 15 h / 60 °C
View Scheme
参考文献
Miller, R. D.; Goelitz, P.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1616 - 1618
