Alpha-甲基-2-噻吩乙酸合成路线 （共 15 条）
反应条件
1.1: LDA / hexane; tetrahydrofuran / 0.5 h / -78 °C
1.2: 97 percent / tetrahydrofuran; hexane / 1 h / -78 - 20 °C
2.1: 72 percent / KOH / ethanol / 1 h / 0 °C
3.1: arylmalonate decarboxylase G74C/C188S / various solvent(s) / 72 h / pH 8.5
View Scheme
参考文献
Ijima, Yoichiro; Matoishi, Kaori; Terao, Yosuke; Doi, Nobuhide; Yanagawa, Hiroshi; Ohta, Hiromichi
Chemical Communications, 2005 , # 7 p. 877 - 879
反应条件
1: CH2Cl2 / 1 h / 40 °C
2: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min
3: ethan. KOH / ethanol / 24 h / Heating
View Scheme
参考文献
Gualtieri; Conti; Dei; Giovannoni; Nannucci; Romanelli; Scapecchi; Teodori; Fanfani; Ghelardini; Giotti; Bartolini
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1704 - 1711
反应条件
1: SO2Cl / 1 h / 60 °C
2: CH2Cl2 / 1 h / 40 °C
3: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min
4: ethan. KOH / ethanol / 24 h / Heating
View Scheme
参考文献
Gualtieri; Conti; Dei; Giovannoni; Nannucci; Romanelli; Scapecchi; Teodori; Fanfani; Ghelardini; Giotti; Bartolini
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1704 - 1711
反应条件
sodium hydroxide; calcium carbonate
1.) aq. MeOH, reflux, 21 h; Yield given. Multistep reaction;
参考文献
Tsuchihashi, Gen-ichi; Kitajima, Koji; Mitamura, Shuichi
Tetrahedron Letters, 1981 , vol. 22, # 43 p. 4305 - 4308
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -30 deg C, 0.5 h, 2.) THF, -30 deg C, 1 h
2: 96 percent / 5percent sodium hydroxide / 2 h / Ambient temperature
View Scheme
参考文献
Kumamoto, Takanobu; Hosoya, Kumiko; Kanzaki, Satoshi; Masuko, Kazuhiro; Watanabe, Mikio; Shirai, Kozo
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 10 p. 3097 - 3102
