(2-甲基-6-硝基苯基)甲醇合成路线 （共 6 条）
反应条件
3,5-dimethyl-1H-pyrazole; Magtrievetrade; in dichloromethane T=20°C; 0.75 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 100 ;
WO 2005/066136 A1
反应条件
sodium tetrahydroborate; boron trifluoride dimethyl etherate in tetrahydrofuran
T=0 - 20°C;
参考文献
McAllister, Laura A.; Bechle, Bruce M.; Dounay, Amy B.; Evrard, Edelweiss; Gan, Xinmin; Ghosh, Somraj; Kim, Ji-Young; Parikh, Vinod D.; Tuttle, Jamison B.; Verhoest, Patrick R.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3484 - 3497
反应条件
1: With pyridine; 2,4,6-tri-fluoro-1,3,5-triazine in dichloromethane
T=-10°C; 1 h;
2: With sodium tetrahydroborate in methanol; dichloromethane
T=20°C; 0.166667 h;
3: With sulfuric acid in methanol; dichloromethane; water
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 99-100 ;
WO 2005/066136 A1
反应条件
sodium tetrahydroborate in tetrahydrofuran; N,N-dimethyl-formamide
3 h; Ambient temperature; Yield given;
参考文献
Phillips; Hartman
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 897 - 899
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
ATandT Bell Laboratories
Patent: US5200544 A1, 1993 ;
反应条件
pyridine; thionyl chloride in cyclohexane; water; benzene
参考文献
Bristol-Myers Company
Patent: US31617 E1, 1984 ;
Title/Abstract Full Text Show Details
Bristol-Myers Company
Patent: US3932407 A1, 1976 ;
