6-(4-羟基苯基)吡嗪-3(2H)-酮合成路线 （共 12 条）
反应条件
AlCl3, aluminium chloride in dichloromethane
T=20°C; 19 h;
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
ammonium hydroxide; hydrazine hydrate
1) heating, 2) water, reflux; Yield given. Multistep reaction;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
反应条件
pyridine; oxygen; copper diacetate; sodium carbonate in toluene
T=20 - 100°C; 12 h; chemoselective reaction;
参考文献
Liang, Lei; Yang, Guanyu; Xu, Fengrong; Niu, Yan; Sun, Qi; Xu, Ping
European Journal of Organic Chemistry, 2013 , # 27 p. 6130 - 6136
反应条件
hydrogenchloride in ethanol
2 h; Heating;
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
1: 88 percent / hydrogen / W-2 Raney nickel / methanol; aq. acetic acid / 5 h / Ambient temperature
2: 77 percent / 99percent hydrazine hydrate / aq. ethanol / 2 h / Ambient temperature
3: 80 percent / 10percent HCl / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
1: 1.) N-chlorosuccinimide, pyridine; 2.) Et3N / 1.) chloroform, 60 deg C, 30 min; 2.) 40-50 deg C, 20 min
2: 88 percent / hydrogen / W-2 Raney nickel / methanol; aq. acetic acid / 5 h / Ambient temperature
3: 77 percent / 99percent hydrazine hydrate / aq. ethanol / 2 h / Ambient temperature
4: 80 percent / 10percent HCl / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
1: 77 percent / 99percent hydrazine hydrate / aq. ethanol / 2 h / Ambient temperature
2: 80 percent / 10percent HCl / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
1: trifluoroacetic acid / dichloromethane / 16 h
2: hydrazine hydrate / ethanol / 2.5 h / |Reflux
3: sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt / water / 1.5 h / |Reflux
4: AlCl3, aluminium chloride / dichloromethane / 19 h / 20 °C
View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
1: hydrazine hydrate / ethanol / 2.5 h / |Reflux
2: sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt / water / 1.5 h / |Reflux
3: AlCl3, aluminium chloride / dichloromethane / 19 h / 20 °C
View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
1: sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt / water / 1.5 h / |Reflux
2: AlCl3, aluminium chloride / dichloromethane / 19 h / 20 °C
View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
