2-苯基-2H-1,2,3,4-四唑-5-羧酸合成路线 （共 5 条）
反应条件
2,4,6-triBrPhN3; sodium in ethanol
5 h; RefluxInert atmosphere;
参考文献
Sutherland, Hamish S.; Blaser, Adrian; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Palmer, Brian D.; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 855 - 866
反应条件
1.1: hydrogenchloride; sodium nitrite / water; ethanol / 0.5 h / 0 °C
1.2: 0.5 h / 20 °C
2.1: sodium hydroxide / water; ethanol / 0.5 h / 60 °C
View Scheme
参考文献
ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie
Patent: US2014/154179 A1, 2014 ;
参考文献
Dimroth; Merzbacher
Chemische Berichte, 1910 , vol. 43, p. 2902
反应条件
in methanol; diethyl ether
参考文献
Sutherland, Hamish S.; Blaser, Adrian; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Palmer, Brian D.; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 855 - 866
反应条件
T=150 - 170°C; P=12 Torr; 0.0833333 h;
参考文献
Huisgen, Rolf; Fliege, Werner; Kolbeck, Winfried
Chemische Berichte, 1983 , vol. 116, p. 3027 - 3038
